产品货号：
JN1894
中文名称：
重组小鼠PD-1(程序性细胞死亡蛋白1)
英文名称：
Recombinant Mouse Programmed Cell Death Protein 1
产品规格：
10μg|50μg|500μg|1mg
发货周期：
1～3天
产品价格：
询价
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Leu25-Gln167在C端带有Fc标签。
PD-1质量控制：＞95%(还原性SDS-PAGE)
PD-1制剂：冻干品
PD-1保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。
PD-1复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。
关于PD-1：
Programmed Death-1 (PD-1),firstly cloned from mouse T cell hybridoma 2B4.11,is one member of CD28/CTLA-4 superfamily.PD-1 belongs to type I transmembrane protein and acts as an important immunosuppressive molecule.This family also include members of CD28,CTLA-4 and ICOS.The mouse Programmed Death-1 protein,encoded by PD-1 gene,comprises four parts including a putative 20 aa signal peptide,a 149 aa extracellular region,a 21 aa transmembrane domain and a 98 aa cytoplasmic region.The cytoplamsic tail of PD-1 contains two structural motifs,an immunoreceptor tyrosine-based inhibitory motif (ITIM) and an immunoreceptor tyrosine-based switch motif (ITSM) formed by two tyrosine residues which make the difference in PD-1 signal mediating.Mouse PD-1 is expressed in thymus and shares about 69% aa sequence identity with human PD-1.Recently,programmed death-1 (PD-1) with its ligands,programmed death ligand B7H1 (PD-L1) and B7DC (PD-L2),was found to regulate T-cell activation and tolerance,upon ligand binding,inhibiting T-cell effector functions in an antigen-specific manner.PD-1 gene knocked out mice would induce some autoimmune diseases,which suggests that PD-1 acts as a co-inhibitory molecule actively participating in maintaining peripheral tolerance.Thus,PD-1 may be a useful target for the immunologic therapy of carcinoma,infection,autoimmune diseases as well as organ transplantation.
相关搜索：重组小鼠PD-1(程序性细胞死亡蛋白1)，PD-1，CD279，Pdcd1，mPD-1，Recombinant Mouse Programmed Cell Death Protein 1
PD-1质量控制：＞95%(还原性SDS-PAGE)
PD-1制剂：冻干品
PD-1保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。
PD-1复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。
关于PD-1：
Programmed Death-1 (PD-1),firstly cloned from mouse T cell hybridoma 2B4.11,is one member of CD28/CTLA-4 superfamily.PD-1 belongs to type I transmembrane protein and acts as an important immunosuppressive molecule.This family also include members of CD28,CTLA-4 and ICOS.The mouse Programmed Death-1 protein,encoded by PD-1 gene,comprises four parts including a putative 20 aa signal peptide,a 149 aa extracellular region,a 21 aa transmembrane domain and a 98 aa cytoplasmic region.The cytoplamsic tail of PD-1 contains two structural motifs,an immunoreceptor tyrosine-based inhibitory motif (ITIM) and an immunoreceptor tyrosine-based switch motif (ITSM) formed by two tyrosine residues which make the difference in PD-1 signal mediating.Mouse PD-1 is expressed in thymus and shares about 69% aa sequence identity with human PD-1.Recently,programmed death-1 (PD-1) with its ligands,programmed death ligand B7H1 (PD-L1) and B7DC (PD-L2),was found to regulate T-cell activation and tolerance,upon ligand binding,inhibiting T-cell effector functions in an antigen-specific manner.PD-1 gene knocked out mice would induce some autoimmune diseases,which suggests that PD-1 acts as a co-inhibitory molecule actively participating in maintaining peripheral tolerance.Thus,PD-1 may be a useful target for the immunologic therapy of carcinoma,infection,autoimmune diseases as well as organ transplantation.
相关搜索：重组小鼠PD-1(程序性细胞死亡蛋白1)，PD-1，CD279，Pdcd1，mPD-1，Recombinant Mouse Programmed Cell Death Protein 1